Public Health England was abolished in 2021 and its functions were re-distributed. Two new national organisations were created: the United Kingdom Health Security Agency (UKHSA) which predominantly has a remit for health protection functions, and the Office for Health Improvement and Disparities (OHID) which has the functions of health improvement, wider determinants of health, and inequalities. NHSE/I has taken responsibility for immunisations, screening, and health services (some of these have a joint responsibility with OHID). Following a series of workshops with leaders from across the public health system, the FPH published this paper summarising leadership perspectives on priorities and ambitions for system working in the new structure. Key priorities explored in the paper include; systems leadership, workforce development, emergency preparedness and response, evaluating and communicating impact, and standards.