The impact of Covid-19 will reverberate throughout communities on a previously unimaginable scale, requiring sustained action from national and local leaders across every sector. This NHS Reset report looks beyond the immediate health response to the pandemic to understand where and how the NHS is actively supporting the nation’s economic and social recovery. Through the NHS Reset campaign, we have been exploring what the health and care sector can do to play a leading role in place-based economic and social recovery and reset. Five key steps will be crucial to enabling every local economy to do so: developing an anchor network across all health and care bodies within a system footprint; making an explicit commitment to fill existing health and care vacancies with local people; embedding health and care within national and local regeneration planning; proposing a Civic Restoration Strategy; and convening industry leaders to source potential new local supply chains. This report outlines what these points look like in practice, with innovative case studies from across the country.