The Francis Report detailed some of the worst failings in care and unnecessary harm to have occurred in the NHS. The government announced a series of measures they hope will deliver a culture of zero-harm and patient-centred care in the NHS. There is a large evidence base that the NHS can draw upon to inform their efforts to improve patient safety. The ten key practices highlighted in this bulletin range from establishing a culture for patient safety through to interventions aimed at reducing specific events. Clear and visible leadership, engagement of front-line clinical staff and interventions that target prevailing attitudes are key. Delivering harm free care should involve routine monitoring of meaningful outcomes. Areas of concern can be identified and targeted so that improvements can be sustained.